Estimation of individual genetic and environmental factor scores

Genet Epidemiol. 1990;7(1):83-91. doi: 10.1002/gepi.1370070115.

Abstract

Implicit in the application of the common-factor model as a method for decomposing trait covariance into a genetic and environmental part is the use of factor scores. In multivariate analyses, it is possible to estimate these factor scores for the communal part of the model. Estimation of scores on latent factors in terms of individual observations within the context of a twin/family study amounts to estimation of individual genetic and environmental scores. Such estimates may be of both theoretical and practical interest and may be provided with confidence intervals around the individual estimates. The method is first illustrated with stimulated twin data and next is applied to blood pressure data obtained in a Dutch sample of 59 male adolescent twin pairs. Subjects with high blood pressure can be distinguished into groups with high genetic or high environmental scores.

MeSH terms

  • Adolescent
  • Blood Pressure / genetics
  • Computer Simulation
  • Confidence Intervals
  • Environment
  • Factor Analysis, Statistical
  • Genetic Techniques*
  • Genetic Variation / genetics*
  • Humans
  • Male
  • Mathematics
  • Models, Genetic
  • Multivariate Analysis
  • Twins / genetics