Abstract
MicroRNAs are small non-coding RNAs that mediate post-transcriptional gene silencing. Fear-extinction learning in C57/Bl6J mice led to increased expression of the brain-specific microRNA miR-128b, which disrupted stability of several plasticity-related target genes and regulated formation of fear-extinction memory. Increased miR-128b activity may therefore facilitate the transition from retrieval of the original fear memory toward the formation of a new fear-extinction memory.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Behavior, Animal
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Brain / metabolism*
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Cell Adhesion Molecules, Neuronal / metabolism
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Cell Line, Transformed
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Conditioning, Classical
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Cyclic AMP Response Element-Binding Protein / metabolism
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Extinction, Psychological / physiology*
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Extracellular Matrix Proteins / metabolism
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Fear*
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Gene Expression Regulation / drug effects
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Gene Expression Regulation / genetics
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Humans
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Male
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Memory / physiology*
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Mice
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Mice, Inbred C57BL
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MicroRNAs / genetics
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MicroRNAs / metabolism*
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Nerve Tissue Proteins / metabolism
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Potassium Chloride / pharmacology
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Protein Phosphatase 1 / metabolism
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RNA, Small Interfering / metabolism
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Reelin Protein
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Serine Endopeptidases / metabolism
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Trans-Activators / metabolism
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Transduction, Genetic / methods
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Transfection
Substances
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Cell Adhesion Molecules, Neuronal
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Creb1 protein, mouse
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Cyclic AMP Response Element-Binding Protein
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Extracellular Matrix Proteins
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MicroRNAs
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Mirn128 microRNA, mouse
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Nerve Tissue Proteins
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RNA, Small Interfering
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Reelin Protein
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Trans-Activators
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Potassium Chloride
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Protein Phosphatase 1
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Serine Endopeptidases