Time trends and age-period-cohort analyses on incidence rates of nasopharyngeal carcinoma during 1993-2007 in Wuhan, China

Cancer Epidemiol. 2012 Feb;36(1):8-10. doi: 10.1016/j.canep.2011.07.002. Epub 2011 Aug 16.

Abstract

Background: Declines in incidence rates of nasopharyngeal carcinoma (NPC) were observed in Hong Kong and Taiwan but not other high-risk regions in China, while evidences from low-risk regions in China are still lacking. This study aimed to examine the time trends (1993-2007) of NPC in Wuhan (a low-risk region) and assess the birth cohort and calendar period effects on the observed temporal trends.

Method: Using data from Wuhan Cancer Registry, age-standardized annual incidence rates of NPC were calculated by the direct method using the WHO World Standard Population (2000) as the reference. Trend in incidence rates of NPC during 1993-2007 was evaluated. Age-period-cohort models were also applied to assess the effects of age, calendar time and birth cohort on the observed temporal trends.

Results: A total of 1685 new NPC cases (1210 males and 475 females) were diagnosed during 1993-2007 in Wuhan. The annual percentage change in incidence rates of NPC were 0.15% (95% confidence interval: -3.88% to 4.34%) for males and -1.17% (95% confidence interval: -4.85% to 2.66%) for females. No obvious cohort or period effect on the incidence rates of NPC was observed.

Conclusion: The incidence rates of NPC remained stable during 1993-2007 in Wuhan, a low-risk region in China.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • China / epidemiology
  • Cohort Studies
  • Female
  • Humans
  • Incidence
  • Male
  • Nasopharyngeal Neoplasms / epidemiology*
  • Nasopharyngeal Neoplasms / mortality
  • Registries
  • Survival Analysis
  • Young Adult