Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) meningitis is associated with a high mortality rate. Treatment is challenging in patients with allergy to vancomycin. Herein, we describe a case of MRSA bacteremia secondary to medical device infection with MRSA that was complicated by MRSA meningitis. This case provides evidence for a possible role of combination therapy of daptomycin, linezolid, and rifampin in cases of MRSA meningitis and bacteremia.
Copyright © 2011 Elsevier Inc. All rights reserved.
MeSH terms
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Acetamides / pharmacology
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Acetamides / therapeutic use
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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Bacteremia / drug therapy*
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Daptomycin / pharmacology
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Daptomycin / therapeutic use
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Drug Therapy, Combination
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Humans
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Linezolid
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Male
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Meningitis, Bacterial / drug therapy*
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Methicillin-Resistant Staphylococcus aureus / isolation & purification
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Microbial Sensitivity Tests
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Middle Aged
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Oxazolidinones / pharmacology
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Oxazolidinones / therapeutic use
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Rifampin / pharmacology
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Rifampin / therapeutic use
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Staphylococcal Infections / drug therapy*
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Treatment Outcome
Substances
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Acetamides
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Anti-Bacterial Agents
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Oxazolidinones
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Linezolid
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Daptomycin
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Rifampin