The authors report the initial results of the combined use of stereotaxic X-rays and fine-needle aspiration biopsy in 83 patients with nonpalpable breast lesions. The stereotaxic system employed is a simple accessory of conventional mammographic equipment. Cytologic diagnosis (94 biopsies) had 90% sensitivity and 97% specificity; the percentage of acellular/insufficient cytologic samples was 10.8%. To assess the clinical value of this technique, the obtained results were compared with both mammographic findings and US-guided aspiration biopsy data.