MitoBamAnnotator: A web-based tool for detecting and annotating heteroplasmy in human mitochondrial DNA sequences

Ilia Zhidkov; Tal Nagar; Dan Mishmar; Eitan Rubin

doi:10.1016/j.mito.2011.08.005

MitoBamAnnotator: A web-based tool for detecting and annotating heteroplasmy in human mitochondrial DNA sequences

Mitochondrion. 2011 Nov;11(6):924-8. doi: 10.1016/j.mito.2011.08.005. Epub 2011 Aug 22.

Authors

Ilia Zhidkov¹, Tal Nagar, Dan Mishmar, Eitan Rubin

Affiliation

¹ National Institute for Biotechonology in the Negev, Beer Sheva, Israel.

PMID: 21875693
DOI: 10.1016/j.mito.2011.08.005

Abstract

The use of Next-Generation Sequencing of mitochondrial DNA is becoming widespread in biological and clinical research. This, in turn, creates a need for a convenient tool that detects and analyzes heteroplasmy. Here we present MitoBamAnnotator, a user friendly web-based tool that allows maximum flexibility and control in heteroplasmy research. MitoBamAnnotator provides the user with a comprehensively annotated overview of mitochondrial genetic variation, allowing for an in-depth analysis with no prior knowledge in programming.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Computational Biology / methods*
DNA, Mitochondrial / genetics*
Genetic Variation*
Humans
Internet
Mutation*

Substances

DNA, Mitochondrial