Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs

Bridgeen McCaughan; Claire Rouanet; Colin Fowley; Nikolitsa Nomikou; Anthony P McHale; Paul A McCarron; John F Callan

doi:10.1016/j.bmcl.2011.08.015

Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs

Bioorg Med Chem Lett. 2011 Oct 1;21(19):5750-2. doi: 10.1016/j.bmcl.2011.08.015. Epub 2011 Aug 10.

Authors

Bridgeen McCaughan¹, Claire Rouanet, Colin Fowley, Nikolitsa Nomikou, Anthony P McHale, Paul A McCarron, John F Callan

Affiliation

¹ Department of Pharmacy and Pharmaceutical Sciences, School of Biomedical Sciences, The University of Ulster, Northern Ireland BT52 1SA, United Kingdom.

PMID: 21875807
DOI: 10.1016/j.bmcl.2011.08.015

Abstract

A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
CHO Cells
Cell Death*
Cell Line, Tumor
Cell Survival
Cricetinae
Drug Evaluation, Preclinical
Lethal Dose 50
Light*
Methylene Blue / chemistry
Methylene Blue / pharmacology*
Oxidation-Reduction
Photosensitizing Agents / chemistry
Photosensitizing Agents / pharmacology*
Reactive Oxygen Species / metabolism*
Rose Bengal / metabolism
Rose Bengal / pharmacology*
Sound*

Substances

Photosensitizing Agents
Reactive Oxygen Species
Rose Bengal
Methylene Blue