Abstract
The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A-C (1-3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5″-dihydrohygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1-3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Bacillus subtilis / drug effects
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Cinnamates / chemistry
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Cinnamates / isolation & purification
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Escherichia coli / drug effects
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Hygromycin B / analogs & derivatives
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Hygromycin B / chemistry
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Hygromycin B / isolation & purification
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Listeria monocytogenes / drug effects
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Macrolides / chemistry
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Macrolides / isolation & purification*
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Macrolides / pharmacology
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Metabolome
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Microbial Sensitivity Tests
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Molecular Structure
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Staphylococcus aureus / drug effects
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Streptomyces* / chemistry
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Streptomyces* / genetics
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Streptomyces* / metabolism
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Vibrio / drug effects
Substances
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Anti-Bacterial Agents
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Cinnamates
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Macrolides
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chaxalactin A
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chaxalactin B
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chaxalactin C
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Hygromycin B
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hygromycin A