New insight into marine alkaloid metabolic pathways: revisiting oroidin biosynthesis

Chembiochem. 2011 Oct 17;12(15):2298-301. doi: 10.1002/cbic.201100449. Epub 2011 Aug 31.

Abstract

Sponge natural product biosynthesis: A highly sensitive in vivo protocol based on (14)C radiolabeled precursors and beta-imager autoradiography allowed the unraveling of the origin of the pyrrole 2-aminoimidazole-containing key biosynthetic intermediate oroidin. Proline and lysine are now proposed as the early precursors of the pyrrole and the 2-aminoimidazole moieties of oroidin respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / metabolism*
  • Animals
  • Axinella / metabolism*
  • Imidazoles / metabolism
  • Lysine / metabolism
  • Metabolic Networks and Pathways
  • Proline / metabolism
  • Pyrroles / metabolism*

Substances

  • Alkaloids
  • Imidazoles
  • Pyrroles
  • pyrrole-2-aminoimidazole
  • Proline
  • Lysine
  • oroidin