Abstract
Flavonoids are a large class of compounds widely distributed in nature. Many pharmacological activities of flavonoids have been reported such as anti-cancer, antioxidant, anti-inflammatory, hepatoprotective, antithrombotic, vasodilator, antiviral, antibacterial, antiallergic, and so on. In recent years, domestic and foreign research groups choose natural flavonoids and optimize their chemical structures in order to develop a number of new derivatives with stronger pharmacological activities. As part of the mechanisms are not clear, we need to strengthen in-depth research in the SAR (structure-activity relationship) study for targeted and efficient structure optimization. This paper systematically summarize current researches in the SAR studies of flavonoids and their derivatives, which can serve as a reference for synthesizing new flavonoid derivatives.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Antioxidants / chemistry
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Antioxidants / pharmacology
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Antisepsis
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Fibrinolytic Agents / chemistry
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Fibrinolytic Agents / pharmacology
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Flavonoids / chemistry*
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Flavonoids / isolation & purification
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Flavonoids / pharmacology*
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Humans
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Plants, Medicinal / chemistry*
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Structure-Activity Relationship
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Vasodilator Agents / chemistry
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Vasodilator Agents / pharmacology
Substances
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Anti-Bacterial Agents
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Anti-Inflammatory Agents
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Antineoplastic Agents
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Antioxidants
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Antiviral Agents
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Fibrinolytic Agents
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Flavonoids
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Vasodilator Agents