Abstract
In the presence of copper(I) iodide, heteroaromatic β-iodo-α,β-unsaturated carboxylic acid systems opposed to terminal alkyne afford selectively 6-endo-dig cyclization products via a tandem coupling oxacyclization reaction.
MeSH terms
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Alkynes / chemistry
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Carboxylic Acids / chemistry
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Catalysis
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Chemistry, Pharmaceutical / methods*
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Copper / chemistry
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Cyclization
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Indoles / chemical synthesis*
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Iodides / chemistry
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Magnetic Resonance Spectroscopy
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Pyrans / chemical synthesis*
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Stereoisomerism
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Thiophenes / chemical synthesis*
Substances
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Alkynes
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Carboxylic Acids
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Indoles
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Iodides
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Pyrans
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Thiophenes
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Copper