RIG-I-like receptors: cytoplasmic sensors for non-self RNA

Immunol Rev. 2011 Sep;243(1):91-8. doi: 10.1111/j.1600-065X.2011.01052.x.

Abstract

Viral infection results in the generation of non-self RNA species in the cells, which is recognized by retinoic acid inducible gene-I-like receptors (RLRs), and initiates innate antiviral responses, including the production of proinflammatory cytokines and type I interferon. In this review, we summarize reports on virus-specificity of RLRs, structures of non-self RNA patterns, structural biology of RLRs, and the signaling adapter molecules involved in antiviral innate immunity.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / immunology*
  • Animals
  • Antigens, Viral / chemistry
  • Antigens, Viral / immunology
  • Cytoplasm / immunology
  • Host-Pathogen Interactions
  • Humans
  • Immunity, Innate
  • Inflammation Mediators / immunology
  • Interferon Type I / immunology*
  • Molecular Structure
  • RNA, Viral / chemistry
  • RNA, Viral / immunology
  • Receptors, Pattern Recognition / immunology*
  • Receptors, Retinoic Acid / immunology*
  • Signal Transduction / immunology
  • Virus Diseases / immunology*
  • Virus Diseases / virology

Substances

  • Adaptor Proteins, Signal Transducing
  • Antigens, Viral
  • Inflammation Mediators
  • Interferon Type I
  • PLAAT4 protein, human
  • RNA, Viral
  • Receptors, Pattern Recognition
  • Receptors, Retinoic Acid