Mannose-binding lectin (MBL2) polymorphisms and inflammation in hypertensive patients

R Schreiber; A V Campos-Coelho; L Brandão; R L Guimarães; A J Kamada; M C Ferreira-Sae; J R Matos-Souza; J A Cipolli; J L de Lima-Filho; S Crovella; W Nadruz Jr

doi:10.1111/j.1744-313X.2011.01036.x

Mannose-binding lectin (MBL2) polymorphisms and inflammation in hypertensive patients

Int J Immunogenet. 2011 Dec;38(6):525-7. doi: 10.1111/j.1744-313X.2011.01036.x. Epub 2011 Sep 6.

Authors

R Schreiber¹, A V Campos-Coelho, L Brandão, R L Guimarães, A J Kamada, M C Ferreira-Sae, J R Matos-Souza, J A Cipolli, J L de Lima-Filho, S Crovella, W Nadruz Jr

Affiliation

¹ Department of Internal Medicine, University of Campinas, Campinas, Brazil.

PMID: 21895981
DOI: 10.1111/j.1744-313X.2011.01036.x

Abstract

We investigated the possible role of Mannose binding lectin 2 (MBL2) functional polymorphisms in the prevalence of hypertension and hypertensive end-organ damage in 300 hypertensive patients and 313 normotensive individuals from Southern Brazil. Hypertensive subjects with MBL2 AO/OO genotypes presented lower C-reactive protein levels than AA individuals and consequently lower inflammatory status.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Brazil
C-Reactive Protein / metabolism
Female
Genetic Predisposition to Disease*
Humans
Hypertension / complications*
Hypertension / genetics*
Inflammation / complications*
Inflammation / genetics*
Male
Mannose-Binding Lectin / genetics*
Middle Aged
Polymorphism, Single Nucleotide / genetics*

Substances

MBL2 protein, human
Mannose-Binding Lectin
C-Reactive Protein