Low frequency of Toll-like receptors 2 and 4 gene polymorphisms in Mexican patients and their association with type 2 diabetes

C Maldonado-Bernal; A Trejo-de la O; M E Sánchez-Contreras; N Wacher-Rodarte; J Torres; M Cruz

doi:10.1111/j.1744-313X.2011.01035.x

Low frequency of Toll-like receptors 2 and 4 gene polymorphisms in Mexican patients and their association with type 2 diabetes

Int J Immunogenet. 2011 Dec;38(6):519-23. doi: 10.1111/j.1744-313X.2011.01035.x. Epub 2011 Sep 9.

Authors

C Maldonado-Bernal¹, A Trejo-de la O, M E Sánchez-Contreras, N Wacher-Rodarte, J Torres, M Cruz

Affiliation

¹ Hospital de Pediatría, Centro Médico Nacional SXXI, IMSS, México City, México. [email protected]

PMID: 21902816
DOI: 10.1111/j.1744-313X.2011.01035.x

Abstract

Type 2 diabetes (T2D) is characterized by a chronic low-grade inflammatory state. SNP in Toll-like receptor (TLR) genes has been associated with impaired inflammatory response. We genotyped the TLR4/D299G, TLR4/T399I and TLR2/R753Q polymorphisms. Low frequency was found with no association with T2D, nevertheless the TLR2 SNP was associated with lower levels in HDL-cholesterol values.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alleles
Diabetes Mellitus, Type 2 / genetics*
Female
Gene Frequency / genetics*
Genetic Association Studies*
Genetic Predisposition to Disease*
Humans
Male
Mexico
Polymorphism, Single Nucleotide / genetics*
Toll-Like Receptor 2 / genetics*
Toll-Like Receptor 4 / genetics*

Substances

TLR2 protein, human
TLR4 protein, human
Toll-Like Receptor 2
Toll-Like Receptor 4