Synthetic antitumor vaccines containing MUC1 glycopeptides with two immunodominant domains-induction of a strong immune response against breast tumor tissues

Angew Chem Int Ed Engl. 2011 Oct 10;50(42):9977-81. doi: 10.1002/anie.201104529. Epub 2011 Sep 9.

Abstract

A shot in the arm for cancer treatment: two MUC1 tetanus toxoid vaccines were synthesized and induced a strong immune response in mice. The antibodies elicited by the vaccines show a high selectivity for the tumor cells in mammary carcinoma tissues and also distinguish between tumor tissues at different stages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / immunology
  • Antineoplastic Agents / pharmacology*
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / immunology
  • Breast Neoplasms / pathology
  • Cancer Vaccines / chemical synthesis
  • Cancer Vaccines / immunology
  • Cancer Vaccines / pharmacology*
  • Drug Screening Assays, Antitumor
  • Female
  • Glycopeptides / chemistry
  • Glycopeptides / immunology*
  • MCF-7 Cells
  • Mammary Neoplasms, Experimental / drug therapy*
  • Mammary Neoplasms, Experimental / immunology
  • Mammary Neoplasms, Experimental / pathology
  • Mice
  • Mice, Inbred BALB C
  • Molecular Conformation
  • Mucin-1 / chemistry
  • Mucin-1 / immunology*
  • Vaccines, Synthetic / chemistry
  • Vaccines, Synthetic / immunology
  • Vaccines, Synthetic / pharmacology*

Substances

  • Antineoplastic Agents
  • Cancer Vaccines
  • Glycopeptides
  • Mucin-1
  • Vaccines, Synthetic