Differences in cerebral blood flow between missed and generalized seizures with electroconvulsive therapy: a positron emission tomographic study

Harumasa Takano; Nobutaka Motohashi; Takeshi Uema; Ken'ichi Ogawa; Takashi Ohnishi; Masami Nishikawa; Hiroshi Matsuda

doi:10.1016/j.eplepsyres.2011.08.007

Differences in cerebral blood flow between missed and generalized seizures with electroconvulsive therapy: a positron emission tomographic study

Epilepsy Res. 2011 Nov;97(1-2):225-8. doi: 10.1016/j.eplepsyres.2011.08.007. Epub 2011 Sep 13.

Authors

Harumasa Takano¹, Nobutaka Motohashi, Takeshi Uema, Ken'ichi Ogawa, Takashi Ohnishi, Masami Nishikawa, Hiroshi Matsuda

Affiliation

¹ Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187-8551, Japan.

PMID: 21917425
DOI: 10.1016/j.eplepsyres.2011.08.007

Abstract

While examining the acute effects of electroconvulsive therapy (ECT) on regional cerebral blood flow (rCBF), we could compare the changes in rCBF between missed (not generalized) and generalized seizures using H(2)(15)O positron emission tomography in patients with depression under anesthesia. In contrast to missed seizures, rCBF was increased extensively, particularly in the centrencephalic structures in generalized seizures. These results further support the centrencephalic theory of seizure generalization.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Anesthesia
Brain / blood supply
Brain / physiology
Cerebrovascular Circulation / physiology*
Depressive Disorder, Major / therapy*
Electroconvulsive Therapy / methods*
Female
Humans
Male
Middle Aged
Oxygen Radioisotopes
Positron-Emission Tomography / methods*
Seizures / physiopathology*

Substances

Oxygen Radioisotopes