Usefulness of three-channel multiplex real-time PCR and melting curve analysis for simultaneous detection and identification of the Mycobacterium tuberculosis complex and nontuberculous mycobacteria

J Clin Microbiol. 2011 Nov;49(11):3963-6. doi: 10.1128/JCM.05662-11. Epub 2011 Sep 14.

Abstract

We attempted to determine the benefits of three-channel multiplex real-time PCR and melting curve analysis not only in detecting and distinguishing between nontuberculous mycobacteria (NTM) and the Mycobacterium tuberculosis complex but also in identifying NTM to the species level.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteriological Techniques / methods*
  • Humans
  • Multiplex Polymerase Chain Reaction / methods*
  • Mycobacterium Infections / diagnosis*
  • Mycobacterium Infections / microbiology*
  • Mycobacterium tuberculosis / classification
  • Mycobacterium tuberculosis / genetics
  • Mycobacterium tuberculosis / isolation & purification*
  • Nontuberculous Mycobacteria / classification
  • Nontuberculous Mycobacteria / genetics
  • Nontuberculous Mycobacteria / isolation & purification*
  • Real-Time Polymerase Chain Reaction / methods*
  • Transition Temperature