FISH analysis reveals frequent co-occurrence of 4q24/TET2 and 5q and/or 7q deletions

Leuk Res. 2012 Jan;36(1):37-41. doi: 10.1016/j.leukres.2011.08.004. Epub 2011 Sep 13.

Abstract

We investigated TET2 deletion in 418 patients with hematological malignancies. Overall interphase FISH detected complete or partial TET2 monoallelic deletion (TET2(del)) in 20/418 cases (4.7%). TET2(del) was very rare in lymphoid malignancies (1/242 cases; 0.4%). Among 19 positive myeloid malignancies TET2(del) was associated with a 4q24 karyotypic abnormality in 18 cases. In AML, TET2(del) occurred in CD34-positive hematopoietic precursors and preceded established genomic abnormalities, such as 5q- and -7/7q-, which were the most frequent associated changes (Fisher's exact test P=0.000).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Child
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 4* / genetics
  • Chromosomes, Human, Pair 5* / genetics
  • Chromosomes, Human, Pair 7* / genetics
  • DNA-Binding Proteins / genetics*
  • Data Interpretation, Statistical
  • Dioxygenases
  • Female
  • Hematologic Neoplasms / epidemiology
  • Hematologic Neoplasms / genetics*
  • Humans
  • In Situ Hybridization, Fluorescence / statistics & numerical data
  • Karyotyping
  • Male
  • Middle Aged
  • Mutation Rate
  • Proto-Oncogene Proteins / genetics*

Substances

  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • Dioxygenases
  • TET2 protein, human