Combination of π-π stacking and electrostatic repulsion between carboxylic carbon nanoparticles and fluorescent oligonucleotides for rapid and sensitive detection of thrombin

Jinhua Liu; Jishan Li; Ying Jiang; Sheng Yang; Weihong Tan; Ronghua Yang

doi:10.1039/c1cc14445f

Combination of π-π stacking and electrostatic repulsion between carboxylic carbon nanoparticles and fluorescent oligonucleotides for rapid and sensitive detection of thrombin

Chem Commun (Camb). 2011 Oct 28;47(40):11321-3. doi: 10.1039/c1cc14445f. Epub 2011 Sep 15.

Authors

Jinhua Liu¹, Jishan Li, Ying Jiang, Sheng Yang, Weihong Tan, Ronghua Yang

Affiliation

¹ State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.

PMID: 21922082
DOI: 10.1039/c1cc14445f

Abstract

On the basis of simultaneous electrostatic repulsion and π-π stacking interactions of carboxylic carbon nanoparticles (cCNPs) with single-stranded DNA, a noncovalent assembly of cCNPs and fluorescent aptamers is reported for rapid, sensitive, and selective detection of thrombin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Aptamers, Nucleotide / chemistry
Biosensing Techniques / methods*
Carbon / chemistry*
Carboxylic Acids / chemistry*
Cattle
Fluorescent Dyes / chemistry
Humans
Nanoparticles / chemistry*
Oligodeoxyribonucleotides / chemistry*
Static Electricity*
Thrombin / analysis*
Time Factors

Substances

Aptamers, Nucleotide
Carboxylic Acids
Fluorescent Dyes
Oligodeoxyribonucleotides
Carbon
Thrombin