Invasive infection in an acute myeloblastic leukemia patient due to triazole-resistant Candida tropicalis

Ana Maria Rabelo de Carvalho Parahym; Carolina Maria da Silva; Mariele Porto Carneiro Leão; Michele Chianca Macario; Gustavo Antônio da Trindade Meira Henriques Filho; Neiva Tinti de Oliveira; Rejane Pereira Neves

doi:10.1016/j.diagmicrobio.2011.08.004

Invasive infection in an acute myeloblastic leukemia patient due to triazole-resistant Candida tropicalis

Diagn Microbiol Infect Dis. 2011 Nov;71(3):291-3. doi: 10.1016/j.diagmicrobio.2011.08.004. Epub 2011 Sep 15.

Authors

Ana Maria Rabelo de Carvalho Parahym¹, Carolina Maria da Silva, Mariele Porto Carneiro Leão, Michele Chianca Macario, Gustavo Antônio da Trindade Meira Henriques Filho, Neiva Tinti de Oliveira, Rejane Pereira Neves

Affiliation

¹ Departamento de Micologia, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Av. Prof. Nelson Chaves, s/no- Cidade Universitária, 50670-420 Recife, Brazil.

PMID: 21924853
DOI: 10.1016/j.diagmicrobio.2011.08.004

Abstract

Non-albicans Candida species are being increasingly reported as causes of nosocomial fungal infections. For example, invasive candidiasis caused by C. tropicalis has been associated with hematologic malignancies. In this study, we report a fatal case of fungemia and a possible urinary and pulmonary infection in a leukemia patient that was due to a strain of C. tropicalis resistant to 2 triazole antifungals.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Antifungal Agents / pharmacology
Antifungal Agents / therapeutic use*
Candida tropicalis / drug effects*
Candida tropicalis / isolation & purification
Candidiasis / complications
Candidiasis / diagnosis
Candidiasis / drug therapy*
Drug Resistance, Fungal
Fatal Outcome
Humans
Leukemia, Myeloid, Acute / complications*
Male
Microbial Sensitivity Tests
Shock, Septic / complications
Triazoles / pharmacology
Triazoles / therapeutic use*

Substances

Antifungal Agents
Triazoles