Basic and therapeutic aspects of angiogenesis

Cell. 2011 Sep 16;146(6):873-87. doi: 10.1016/j.cell.2011.08.039.

Abstract

Blood vessels form extensive networks that nurture all tissues in the body. Abnormal vessel growth and function are hallmarks of cancer and ischemic and inflammatory diseases, and they contribute to disease progression. Therapeutic approaches to block vascular supply have reached the clinic, but limited efficacy and resistance pose unresolved challenges. Recent insights establish how endothelial cells communicate with each other and with their environment to form a branched vascular network. The emerging principles of vascular growth provide exciting new perspectives, the translation of which might overcome the current limitations of pro- and antiangiogenic medicine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiogenesis Inhibitors / pharmacology
  • Angiogenesis Inhibitors / therapeutic use
  • Animals
  • Blood Vessels / cytology
  • Blood Vessels / embryology
  • Endothelial Cells / drug effects
  • Endothelial Cells / physiology
  • Humans
  • Inflammation / drug therapy
  • Neovascularization, Pathologic / drug therapy*
  • Neovascularization, Physiologic*

Substances

  • Angiogenesis Inhibitors