Depressive mood is a common accompaniment of schizophrenia. The present study was taken up with the aim to study the effect of imipramine on depressivse symptoms of schizophrenia. Eighteen patients of schizophrenia with depressive symptoms were studied under a double blind controlled design with a chlorpromazine-imipramine and a chlorpromazine-placebo group. Both the groups showed significant improvement (p< .001) after the 6 week trial and the addition of imipramine to chlorpromazine therapy did not have any advantageous or deleterious effect.