The South Carolina Cancer Prevention and Control Research Network, in partnership with the South Carolina Primary Health Care Association, and Federally Qualified Health Centers (FQHCs), aims to promote evidence-based cancer interventions in community-based primary care settings. Partnership activities include (1) examining FQHCs' readiness and capacity for conducting research, (2) developing a cancer-focused data sharing network, and (3) integrating a farmers' market within an FQHC. These activities identify unique opportunities for public health and primary care collaborations.