Molecular epidemiology of Clostridium difficile strains in children compared with that of strains circulating in adults with Clostridium difficile-associated infection

J Clin Microbiol. 2011 Nov;49(11):3994-6. doi: 10.1128/JCM.05349-11. Epub 2011 Sep 21.

Abstract

Molecular analysis of Clostridium difficile (28 isolates) from children (n = 128) in Oxfordshire, United Kingdom, identified eight toxigenic genotypes. Six of these were isolated from 27% of concurrent adult C. difficile-associated infections studied (n = 83). No children carried hypervirulent PCR ribotype 027. Children could participate in the transmission of some adult disease-causing genotypes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child, Preschool
  • Clostridioides difficile / classification*
  • Clostridioides difficile / genetics
  • Clostridioides difficile / isolation & purification*
  • Clostridium Infections / epidemiology*
  • Clostridium Infections / microbiology*
  • DNA, Bacterial / genetics
  • Genotype
  • Humans
  • Infant
  • Middle Aged
  • Molecular Epidemiology
  • Ribotyping
  • United Kingdom / epidemiology
  • Young Adult

Substances

  • DNA, Bacterial