Genomic analysis at the single-cell level

Annu Rev Genet. 2011:45:431-45. doi: 10.1146/annurev-genet-102209-163607. Epub 2011 Sep 19.

Abstract

Studying complex biological systems such as a developing embryo, a tumor, or a microbial ecosystem often involves understanding the behavior and heterogeneity of the individual cells that constitute the system and their interactions. In this review, we discuss a variety of approaches to single-cell genomic analysis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cells / cytology*
  • Flow Cytometry
  • Genomics / methods*
  • High-Throughput Screening Assays
  • Humans
  • Microscopy
  • Polymerase Chain Reaction / methods
  • Sequence Analysis, RNA
  • Single-Cell Analysis / instrumentation*
  • Single-Cell Analysis / methods*
  • Tissue Array Analysis