RETRACTED: Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models

Mol Cell Neurosci. 2012 Jan;49(1):44-53. doi: 10.1016/j.mcn.2011.09.002. Epub 2011 Sep 14.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Concerns about the article were raised on PubPeer [https://pubpeer.com/publications/DA4525FDCD8F7FEA2E4ACC9EC9322F] namely that in the western blots there are similarities between Fig. 1D and 1E, Fig. 2B duplicates Fig. 3E, Fig. 4L duplicates Fig. 5A and Fig. 4A partly duplicates Fig. 4F, and Figure 2D is the same as Figure 1B in Algarzae, N., Hebron, M., Miessau, M., Moussa, C.E.H., 2012. Parkin prevents cortical atrophy and Ab-induced alterations of brain metabolism: 13C NMR and magnetic resonance imaging studies in AD models. Neuroscience 225, 22-34. The corresponding author was not able to provide the raw data, and therefore requested to retract the article. Authors Charbel E.-H. Moussa, G. William Rebeck and Alexander M. Herman agreed to this retraction, Preeti J. Khandelwal and Sonya B. Dumanis are no longer in science and could not be contacted.

Publication types

  • Research Support, N.I.H., Extramural
  • Retracted Publication

MeSH terms

  • Animals
  • DNA-Binding Proteins / metabolism
  • Gene Transfer Techniques
  • Glycogen Synthase Kinase 3 / metabolism
  • Inflammation / genetics
  • Inflammation / metabolism
  • Interleukin-6 / metabolism
  • Lentivirus / genetics
  • Models, Animal
  • Motor Cortex / metabolism
  • Phosphorylation / physiology
  • Rats
  • Rats, Sprague-Dawley
  • Tauopathies / genetics*
  • Tauopathies / metabolism
  • alpha-Synuclein / genetics
  • alpha-Synuclein / metabolism*
  • tau Proteins / genetics*
  • tau Proteins / metabolism

Substances

  • DNA-Binding Proteins
  • Interleukin-6
  • alpha-Synuclein
  • tau Proteins
  • Glycogen Synthase Kinase 3