Abstract
We investigated the effects of chronic mineralocorticoid receptor blockade with eplerenone on the development and progression of hypertension and end organ damage in Dahl salt-sensitive rats. Eplerenone significantly attenuated the progressive rise in systolic blood pressure (SBP) (204 ± 3 vs. 179±3 mmHg, p < 0.05), reduced proteinuria (605.5 ± 29.6 vs. 479.7 ± 26.1 mg/24h, p < 0.05), improved injury scores of glomeruli, tubules, renal interstitium, and vasculature in Dahl salt-sensitive rats fed a high-salt diet. These results demonstrate that mineralocorticoid receptor antagonism provides target organ protection and attenuates the development of elevated blood pressure (BP) in a model of salt-sensitive hypertension.
MeSH terms
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Aldosterone / blood
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Animals
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Blood Pressure / drug effects
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Chronic Disease
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Creatinine / blood
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Disease Models, Animal
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Disease Progression
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Electrolytes / blood
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Eplerenone
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Heart Rate / drug effects
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Hypertension, Renal / drug therapy*
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Hypertension, Renal / pathology
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Hypertension, Renal / physiopathology
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Kidney / drug effects
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Kidney / pathology
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Kidney / physiology
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Male
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Mineralocorticoid Receptor Antagonists* / blood
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Mineralocorticoid Receptor Antagonists* / pharmacology*
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Organ Size
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Rats
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Rats, Inbred Dahl
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Receptors, Mineralocorticoid / physiology
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Sodium Chloride, Dietary / pharmacology*
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Spironolactone / analogs & derivatives*
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Spironolactone / blood
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Spironolactone / pharmacology
Substances
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Electrolytes
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Mineralocorticoid Receptor Antagonists
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Receptors, Mineralocorticoid
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Sodium Chloride, Dietary
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Spironolactone
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Aldosterone
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Eplerenone
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Creatinine