A "turn-on" fluorescent probe for hypochlorous acid: convenient synthesis, good sensing performance, and a new design strategy by the removal of C=N isomerization

Xiaohong Cheng; Huizhen Jia; Teng Long; Jun Feng; Jingui Qin; Zhen Li

doi:10.1039/c1cc15214a

A "turn-on" fluorescent probe for hypochlorous acid: convenient synthesis, good sensing performance, and a new design strategy by the removal of C=N isomerization

Chem Commun (Camb). 2011 Nov 21;47(43):11978-80. doi: 10.1039/c1cc15214a. Epub 2011 Sep 30.

Authors

Xiaohong Cheng¹, Huizhen Jia, Teng Long, Jun Feng, Jingui Qin, Zhen Li

Affiliation

¹ Department of Chemistry, Hubei Key Laboratory on Organic and Polymeric Optoelectronic Materials, Wuhan University, Wuhan, 430072, China.

PMID: 21959955
DOI: 10.1039/c1cc15214a

Abstract

A new design strategy for the development of fluorescent turn-on chemodosimeters toward OCl(-) was proposed by the removal, but not the general inhibition, of the C=N isomerization. Accordingly, Flu-1 was prepared, which, as shown in the fluorescent picture, exhibited the off-on response for OCl(-), sensitively and selectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbon / chemistry
Fluoresceins / chemical synthesis*
Fluoresceins / chemistry
Fluorescent Dyes / chemistry*
HeLa Cells
Humans
Hypochlorous Acid / chemistry*
Isomerism
Microscopy, Fluorescence
Nitrogen / chemistry
Oximes / chemical synthesis*
Oximes / chemistry
Quantum Theory

Substances

Flu-1 compound
Fluoresceins
Fluorescent Dyes
Oximes
Hypochlorous Acid
Carbon
Nitrogen