Novel head-to-head gene fusion of MLL with ZC3H13 in a JAK2 V617F-positive patient with essential thrombocythemia without blast cells

Leuk Res. 2012 Jan;36(1):e27-30. doi: 10.1016/j.leukres.2011.09.003. Epub 2011 Oct 1.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged, 80 and over
  • Amino Acid Substitution / physiology
  • Base Sequence
  • Blast Crisis / pathology
  • Cell Cycle Proteins / genetics*
  • Gene Fusion* / physiology
  • Histone-Lysine N-Methyltransferase
  • Humans
  • Janus Kinase 2 / genetics*
  • Male
  • Myeloid-Lymphoid Leukemia Protein / genetics*
  • Nuclear Proteins
  • Phenylalanine / genetics
  • Polymorphism, Single Nucleotide / physiology
  • RNA-Binding Proteins
  • Sequence Inversion* / physiology
  • Thrombocythemia, Essential / genetics*
  • Thrombocythemia, Essential / pathology
  • Valine / genetics

Substances

  • Cell Cycle Proteins
  • KMT2A protein, human
  • Nuclear Proteins
  • RNA-Binding Proteins
  • ZC3H13 protein, human
  • Myeloid-Lymphoid Leukemia Protein
  • Phenylalanine
  • Histone-Lysine N-Methyltransferase
  • JAK2 protein, human
  • Janus Kinase 2
  • Valine