Translocation mapping exposes the risky lifestyle of B cells

Rachel Patton McCord; Job Dekker

doi:10.1016/j.cell.2011.09.005

Translocation mapping exposes the risky lifestyle of B cells

Cell. 2011 Sep 30;147(1):20-2. doi: 10.1016/j.cell.2011.09.005.

Authors

Rachel Patton McCord¹, Job Dekker

Affiliation

¹ Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605-0103, USA.

PMID: 21962501
DOI: 10.1016/j.cell.2011.09.005

Abstract

Recurrent chromosomal translocations can drive oncogenesis, but how they form has remained elusive. Now, Chiarle et al. (2011) and Klein et al. (2011) characterize the genome-wide spectrum of translocations that form from a single double-stranded break, revealing that specific loci have an intrinsic predisposition for frequent chromosomal rearrangements.

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