A novel route to copper(II) detection using 'click' chemistry-induced aggregation of gold nanoparticles

Analyst. 2012 Jan 7;137(1):82-6. doi: 10.1039/c1an15693d. Epub 2011 Oct 6.

Abstract

A simple colorimetric method for the detection of copper ions in water is described. This method is based on the 'click' copper(I)-catalyzed azide-alkyne cycloaddition reaction and its use in promoting the aggregation of azide-tagged gold nanoparticles by a dialkyne cross-linker is described. Nanoparticle cross-linking, evidenced as a colour change, is used for the detection of copper ions. The lowest detected concentration by the naked eye was 1.8 μM, with the response linear with log(concentration) between 1.8-200 μM. The selectivity relative to other potentially interfering ions was evaluated.

Publication types

  • Evaluation Study

MeSH terms

  • Alkynes / chemistry
  • Azides / chemistry
  • Biosensing Techniques / instrumentation
  • Biosensing Techniques / methods*
  • Catalysis
  • Cations, Divalent / analysis
  • Click Chemistry / instrumentation
  • Click Chemistry / methods*
  • Colorimetry / methods
  • Copper / analysis*
  • Cross-Linking Reagents / chemistry
  • Cyclization
  • Gold / chemistry*
  • Limit of Detection
  • Metal Nanoparticles / chemistry*
  • Microscopy, Electron, Scanning / methods
  • Water Supply / analysis
  • Water Supply / standards

Substances

  • Alkynes
  • Azides
  • Cations, Divalent
  • Cross-Linking Reagents
  • Gold
  • Copper