Characteristics of arteriovenous malformations associated with cerebral aneurysms

Objective: To analyze the characteristics of brain arteriovenous malformations (AVMs) associated with cerebral aneurysms.

Methods: A total of 302 consecutive, retrospectively reviewed patients from the Beijing Tiantan Hospital were analyzed in this study. The presence of cerebral aneurysm was confirmed by pretherapeutic selective and superselective angiography. Clinical presentation was categorized as intracranial hemorrhage or nonhemorrhagic presentation. Univariate and multivariate statistical models were applied to test the effect of age, sex, AVM size and location, and venous drainage pattern.

Results: Of the 302 patients, 74 (24.5%) had AVMs associated with cerebral aneurysms. AVMs coexisting with aneurysms were significantly associated with hemorrhage at initial presentation (2.27; 95% confidence interval 1.31-3.95; P = 0.003). Infratentorial AVM location was significantly associated with AVMs coexisting with aneurysms (2.31; 95% confidence interval 1.02-5.24; P = 0.040). Deep or superficial venous drainage, female sex, or AVM size were not significantly associated with AVMs coexisting with aneurysms. The regression model showed significant effect was found for initial presentation with hemorrhage (P = 0.003), age (P = 0.003), and infratentorial AVM location (P = 0.040).

Conclusions: Our findings suggest that AVMs associated with cerebral aneurysms are frequently associated with initial hemorrhage presentation and infratentorial AVM location.