One-pot synthesis of chiral nonracemic amines

J Org Chem. 2011 Nov 18;76(22):9452-9. doi: 10.1021/jo201849j. Epub 2011 Oct 18.

Abstract

One-pot five-component reactions of oxathiazolidine-S-oxides with mesitylmagnesium bromide, lithium bis(trimethylsilyl)amide, aldehydes and Grignard reagents afford chiral nonracemic amines or sulfinamides in good yields and high stereoselectivities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Amines / chemical synthesis*
  • Amines / chemistry
  • Lithium Compounds / chemistry*
  • Magnesium Compounds / chemistry*
  • Molecular Structure
  • Stereoisomerism

Substances

  • Aldehydes
  • Amines
  • Lithium Compounds
  • Magnesium Compounds