Abstract
We have studied growth hormone production in a patient with a bronchial carcinoid and acromegaly. The absence of growth hormone from the carcinoid tumour was demonstrated by extraction, cell culture and immunoperosidase techniques. Using a linked perfusion culture system, effluent from the bronchial carcinoid tumour culture stimulated a rapid release of growth hormone from a rat pituitary monolayer. This is the first time evidence of growth hormone releasing activity by a bronchial carcinoid has been demonstrated in a production.
MeSH terms
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Acromegaly / etiology*
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Adrenocorticotropic Hormone / metabolism
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Animals
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Bronchial Neoplasms / complications
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Bronchial Neoplasms / metabolism*
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Carcinoid Tumor / complications
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Carcinoid Tumor / metabolism*
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Cells, Cultured
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Dopamine / pharmacology
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Growth Hormone / biosynthesis
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Growth Hormone / metabolism
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Growth Hormone-Releasing Hormone / metabolism*
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Humans
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Male
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Neoplasm Metastasis
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Pituitary Gland, Anterior / drug effects
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Pituitary Gland, Anterior / metabolism
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Rats
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Secretory Rate / drug effects
Substances
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Adrenocorticotropic Hormone
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Growth Hormone
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Growth Hormone-Releasing Hormone
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Dopamine