Progress toward developing a carbohydrate-conjugate vaccine against Clostridium difficile ribotype 027: synthesis of the cell-surface polysaccharide PS-I repeating unit

Christopher E Martin; Markus W Weishaupt; Peter H Seeberger

doi:10.1039/c1cc13614c

Progress toward developing a carbohydrate-conjugate vaccine against Clostridium difficile ribotype 027: synthesis of the cell-surface polysaccharide PS-I repeating unit

Chem Commun (Camb). 2011 Oct 7;47(37):10260-2. doi: 10.1039/c1cc13614c.

Authors

Christopher E Martin¹, Markus W Weishaupt, Peter H Seeberger

Affiliation

¹ Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Mühlenberg 1, 14476 Potsdam, Germany.

PMID: 21998885
DOI: 10.1039/c1cc13614c

Abstract

Clostridium difficile strain ribotype 027 is a hypervirulent pathogen that is responsible for recent, severe outbreaks of serious nosocomial infections. As a foundation for the development of a preventative carbohydrate-based vaccine, we have synthesized a pentasaccharide cell wall repeating unit from PS-I unique to this strain, by the linear assembly of four monosaccharide building blocks.

MeSH terms

Carbohydrate Sequence
Cell Wall / chemistry
Clostridioides difficile / cytology*
Clostridioides difficile / immunology*
Drug Design*
Molecular Sequence Data
Polysaccharides, Bacterial / chemical synthesis*
Polysaccharides, Bacterial / chemistry*
Polysaccharides, Bacterial / immunology
Vaccines, Conjugate / chemistry
Vaccines, Conjugate / immunology

Substances

Polysaccharides, Bacterial
Vaccines, Conjugate