Correlative magnetic resonance imaging and autopsy findings in a patient with coagulation necrosis treated with tissue plasminogen activator

Miki Suzuki; Toshiki Uchihara; Shuta Toru; Yuan Bae; Toru Igari; Masanobu Kitagawa; Shinichiro Uchiyama; Katsuiku Hirokawa; Takayoshi Kobayashi

doi:10.1016/j.jstrokecerebrovasdis.2010.10.006

Correlative magnetic resonance imaging and autopsy findings in a patient with coagulation necrosis treated with tissue plasminogen activator

J Stroke Cerebrovasc Dis. 2012 Aug;21(6):512-4. doi: 10.1016/j.jstrokecerebrovasdis.2010.10.006. Epub 2011 Oct 13.

Authors

Miki Suzuki¹, Toshiki Uchihara, Shuta Toru, Yuan Bae, Toru Igari, Masanobu Kitagawa, Shinichiro Uchiyama, Katsuiku Hirokawa, Takayoshi Kobayashi

Affiliation

¹ Department of Neurology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan. [email protected]

PMID: 22000524
DOI: 10.1016/j.jstrokecerebrovasdis.2010.10.006

Abstract

Coagulation necrosis is a peculiar type of ischemic necrosis that is characterized by firm, eosinophilic parenchyma with recognizable cell outlines without massive glial reactions. This is an autopsy report of coagulation necrosis 6 months after thrombolytic tissue plasminogen activator therapy against massive cerebral embolism in an 84-year-old man with atrial fibrillation.

Publication types

Case Reports

MeSH terms

Aged, 80 and over
Atrial Fibrillation / complications*
Autopsy
Brain / drug effects
Brain / pathology*
Fatal Outcome
Fibrinolytic Agents / administration & dosage
Fibrinolytic Agents / adverse effects*
Humans
Intracranial Embolism / drug therapy*
Intracranial Embolism / etiology
Intracranial Hemorrhages / chemically induced
Intracranial Hemorrhages / pathology*
Magnetic Resonance Imaging
Male
Necrosis
Thrombolytic Therapy / adverse effects*
Tissue Plasminogen Activator / administration & dosage
Tissue Plasminogen Activator / adverse effects*
Treatment Outcome

Substances

Fibrinolytic Agents
Tissue Plasminogen Activator