Abstract
A series of novel 11H-benzo[a]carbazole-5-carboxamide derivatives were designed, synthesized and evaluated for their antitumor activity against human cancer A549 and HCT-116 cell lines. Most of the compounds showed potent antitumor activities, and compound 8 displayed remarkable in vitro and in vivo anticancer activity comparable to that of amonafide.
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemical synthesis
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Amides / chemistry
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Amides / pharmacology
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Amides / therapeutic use
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use*
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Carbazoles / chemical synthesis
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Carbazoles / chemistry*
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Carbazoles / pharmacology
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Carbazoles / therapeutic use*
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Cell Cycle Checkpoints / drug effects
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Humans
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Mice
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Mice, Nude
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Neoplasms / drug therapy
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Structure-Activity Relationship
Substances
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Amides
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Antineoplastic Agents
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Carbazoles
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carbazole