Circulating CD8+CD56-perforin+ T cells are increased in multiple sclerosis patients

J Neuroimmunol. 2011 Dec 15:240-241:137-41. doi: 10.1016/j.jneuroim.2011.09.002. Epub 2011 Oct 15.

Abstract

Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8+CD56-perforin+ T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8+CD56- T cells than controls. MS patients with EDSS ≥3 showed higher percentage of CD8+CD56-perforin+ T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8+CD56-perforin+ T cells that may play a role in the development of disability.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • CD56 Antigen* / blood
  • CD8-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / pathology
  • Disease Progression
  • Epitopes, T-Lymphocyte / biosynthesis
  • Epitopes, T-Lymphocyte / blood
  • Female
  • Humans
  • Immunophenotyping
  • Lymphocyte Count
  • Male
  • Middle Aged
  • Multiple Sclerosis, Chronic Progressive / immunology*
  • Multiple Sclerosis, Chronic Progressive / pathology
  • Multiple Sclerosis, Relapsing-Remitting / immunology*
  • Multiple Sclerosis, Relapsing-Remitting / pathology
  • Perforin / biosynthesis*
  • Perforin / blood
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / pathology

Substances

  • CD56 Antigen
  • Epitopes, T-Lymphocyte
  • Perforin