Chronic inflammatory lumbosacral polyradiculopathy: a regional variant of CIDP

Muscle Nerve. 2011 Nov;44(5):833-7. doi: 10.1002/mus.22165.

Abstract

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) affects various components and segments of the peripheral nervous system differently, and thus there can be phenotypic heterogeneity. We report a 47-year-old woman with chronic sensory disturbances and proximal weakness limited to the legs. Motor and sensory nerve conduction studies were normal. Somatosensory evoked potentials and imaging indicated a demyelinating process involving the lumbosacral roots. The patient responded favorably to IVIg. Although she did not fulfill the diagnostic criteria for CIDP we believe this patient represents a restricted regional CIDP variant.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Genetic Variation / genetics*
  • Humans
  • Lumbosacral Region / physiopathology*
  • Middle Aged
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / diagnosis*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / genetics*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / physiopathology