Isolated subcutaneous metastasis of osteosarcoma 5 years after initial diagnosis

J Pediatr Surg. 2011 Oct;46(10):2029-31. doi: 10.1016/j.jpedsurg.2011.06.011.

Abstract

The pediatric malignancies most likely to metastasize to the skin are neuroblastoma, leukemia, and rhabdomyosarcoma. Cutaneous and subcutaneous metastases from osteosarcoma are extremely rare, with only a few cases reported in pediatric patients with multifocal synchronous osteosarcoma. We describe the case of a 19-year-old woman with a single subcutaneous nodule of the abdominal wall that, on histologic evaluation, proved to be a metastatic high-grade osteosarcoma 5 years after her initial diagnosis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Abdominal Wall
  • Antibodies, Monoclonal / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bone Neoplasms / drug therapy
  • Bone Neoplasms / pathology*
  • Bone Neoplasms / surgery
  • Calcinosis / diagnostic imaging
  • Calcinosis / etiology
  • Cisplatin / administration & dosage
  • Combined Modality Therapy
  • Doxorubicin / administration & dosage
  • Female
  • Humans
  • Ifosfamide / administration & dosage
  • Lung Neoplasms / secondary
  • Lung Neoplasms / surgery
  • Methotrexate / administration & dosage
  • Neoadjuvant Therapy
  • Organ Sparing Treatments
  • Osteosarcoma / diagnostic imaging
  • Osteosarcoma / drug therapy
  • Osteosarcoma / secondary*
  • Osteosarcoma / surgery
  • Radiography
  • Razoxane / administration & dosage
  • Receptor, IGF Type 1 / immunology
  • Skin Neoplasms / diagnostic imaging
  • Skin Neoplasms / secondary*
  • Skin Neoplasms / surgery
  • Subcutaneous Tissue
  • Tibia / pathology*
  • Tibia / surgery
  • Time Factors
  • Young Adult

Substances

  • Antibodies, Monoclonal
  • Razoxane
  • Doxorubicin
  • Receptor, IGF Type 1
  • Cisplatin
  • Ifosfamide
  • Methotrexate