Enhancement of metabolites productivity of Penicillium pinophilum FKI-5653, by co-culture with Trichoderma harzianum FKI-5655

J Antibiot (Tokyo). 2011 Dec;64(12):769-74. doi: 10.1038/ja.2011.91. Epub 2011 Oct 19.

Abstract

In the course of discovering new metabolites from co-culture of Penicillium pinophilum FKI-5653 and Trichoderma harzianum FKI-5655, a new compound, designated secopenicillide C, and four known compounds, penicillide, MC-141, pestalasin A and stromemycin were isolated. The production of these compounds, except pestalasin A, was enhanced in co-culture to be two to six times higher than in pure culture of Penicillium pinophilum FKI-5653, which was the producer of these compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Coculture Techniques
  • DNA, Fungal / chemistry
  • DNA, Fungal / genetics
  • DNA, Ribosomal Spacer / chemistry
  • DNA, Ribosomal Spacer / genetics
  • Microbiological Techniques / methods
  • Molecular Sequence Data
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Penicillium / genetics
  • Penicillium / metabolism*
  • Penicillium / ultrastructure
  • Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • Spectrometry, Mass, Electrospray Ionization
  • Trichoderma / genetics
  • Trichoderma / metabolism*
  • Trichoderma / ultrastructure

Substances

  • DNA, Fungal
  • DNA, Ribosomal Spacer

Associated data

  • GENBANK/AB604412
  • GENBANK/AB604413