Mitochondrial DNA depletion syndrome-an unusual reason for interstage attrition after the modified stage 1 Norwood operation

Dominic Cave; David B Ross; Wesam Bahitham; Alicia Chan; Consolato Sergi; Ian Adatia

doi:10.1111/j.1747-0803.2011.00569.x

Mitochondrial DNA depletion syndrome-an unusual reason for interstage attrition after the modified stage 1 Norwood operation

Congenit Heart Dis. 2013 Jan-Feb;8(1):E20-3. doi: 10.1111/j.1747-0803.2011.00569.x. Epub 2011 Oct 20.

Authors

Dominic Cave¹, David B Ross, Wesam Bahitham, Alicia Chan, Consolato Sergi, Ian Adatia

Affiliation

¹ Department of Anesthesia and Pediatrics, Stollery Children's Hospital, Mazankowski Heart Institute, University of Alberta, Edmonton, AB, Canada.

PMID: 22011012
DOI: 10.1111/j.1747-0803.2011.00569.x

Abstract

We describe a patient with a variant of the hypoplastic left heart syndrome who died 16 weeks after a modified stage 1 Norwood from a mitochondrial DNA depletion syndrome.

Publication types

Case Reports

MeSH terms

Acidosis, Lactic
DNA, Mitochondrial*
Fatal Outcome
Heart Septal Defects, Ventricular / complications
Humans
Hypoplastic Left Heart Syndrome / blood
Hypoplastic Left Heart Syndrome / complications*
Hypoplastic Left Heart Syndrome / surgery*
Infant, Newborn
Lactic Acid / blood
Liver Failure, Acute / complications
Mitochondrial Diseases / blood
Mitochondrial Diseases / complications*
Norwood Procedures / methods*
Syndrome

Substances

DNA, Mitochondrial
Lactic Acid