Each year, more than one million new AIDS cases are reported worldwide, signaling an immediate need for intervention strategies to combat the physical, immunological, and psychological/emotional complications associated with the disease. In an effort to address this issue, our study contrasted an aerobic exercise intervention with a resistance weight-training intervention for a period of 12 weeks. Each week, participants seropositive for HIV-1 completed a short survey concerning their positive and negative feeling states and perceptions of fatigue immediately following exercise. Results indicated that participants in both exercise groups experienced significantly greater levels of positive well being and significantly lower levels of psychological distress and perceptions of fatigue following exercise sessions engaged in during the final week as compared to sessions engaged in during the initial week.