Aptamer-conjugated nanomaterials and their applications

Adv Drug Deliv Rev. 2011 Nov;63(14-15):1361-70. doi: 10.1016/j.addr.2011.10.002. Epub 2011 Oct 14.

Abstract

The combination of aptamers with novel nanomaterials, including nanomaterial-based aptamer bioconjugates has attracted considerable interest and has led to a wide variety of applications. In this review, we discuss how a variety of nanomaterials, including gold, silica and magnetic nanoparticles, as well as carbon nanotubes, hydrogels, liposomes and micelles, have been used to functionalize aptamers for a variety of applications. These aptamer functionalized materials have led to advances in amplified biosensing, cancer cell-specific recognition, high-efficiency separation, and targeted drug delivery.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Aptamers, Nucleotide / administration & dosage*
  • Aptamers, Nucleotide / chemistry
  • Aptamers, Nucleotide / genetics
  • Biosensing Techniques*
  • Cell Line
  • Drug Carriers / chemistry*
  • Gold / chemistry
  • Humans
  • Hydrogels / chemistry
  • Metal Nanoparticles / chemistry
  • Microscopy, Confocal
  • Nanoparticles / chemistry*
  • Silicon Dioxide / chemistry

Substances

  • Aptamers, Nucleotide
  • Drug Carriers
  • Hydrogels
  • Gold
  • Silicon Dioxide