Abstract
Cancer stem cells (CSCs) share many features with embryonic stem cells (ESCs) such as the ability for self-renewal and differentiation. Signaling pathways that are involved in these processes are also involved in chemo- and radioresistance (e.g. Wnt, Notch and Hedgehog pathways). This review is focused on the influence of three important differentiation pathways on carcinogenesis and on chemo- and radioresistance in ESCs and CSCs.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Differentiation / physiology*
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Cell Transformation, Neoplastic*
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Drug Resistance, Neoplasm / physiology*
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Embryonic Stem Cells / cytology
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Embryonic Stem Cells / physiology
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Gene Expression Regulation, Developmental
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Gene Expression Regulation, Neoplastic
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Hedgehog Proteins / physiology
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Humans
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Neoplasm Proteins / physiology
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Neoplastic Stem Cells / cytology
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Neoplastic Stem Cells / drug effects
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Neoplastic Stem Cells / radiation effects
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Pluripotent Stem Cells / cytology
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Pluripotent Stem Cells / physiology
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Radiation Tolerance / physiology*
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Receptors, Notch / physiology
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Wnt Proteins / physiology
Substances
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Hedgehog Proteins
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Neoplasm Proteins
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Receptors, Notch
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Wnt Proteins