Immunohistochemical detection of parvovirus B19 in "gloves and socks" papular purpuric syndrome: direct evidence for viral endothelial involvement. Report of three cases and review of the literature

Am J Dermatopathol. 2011 Dec;33(8):790-5. doi: 10.1097/DAD.0b013e318221bc41.

Abstract

Papular-purpuric "gloves and socks" syndrome is a distinctive dermatosis featuring acral pruritus, edema, and petechiae. It has been attributed in most--but not all--reported cases to Parvovirus B19 infection, on the grounds of serological proof of recent infection or detection of viral DNA by polymerase chain reaction in patient serum or biopsies. We report the immunohistochemical detection of Parvovirus B19 VP2 structural protein in the endothelial lining of dermal blood vessels in 3 examples of Papular-purpuric "gloves and socks" syndrome and review previously described immunohistochemical investigations in cutaneous involvement by this infection.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Biopsy
  • Capsid Proteins / analysis*
  • DNA, Viral / isolation & purification
  • Edema / virology
  • Female
  • Foot Dermatoses / diagnosis
  • Foot Dermatoses / pathology
  • Foot Dermatoses / virology*
  • Hand Dermatoses / diagnosis
  • Hand Dermatoses / pathology
  • Hand Dermatoses / virology*
  • Humans
  • Immunohistochemistry*
  • Male
  • Middle Aged
  • Parvoviridae Infections / complications
  • Parvoviridae Infections / diagnosis
  • Parvoviridae Infections / pathology
  • Parvoviridae Infections / virology*
  • Parvovirus B19, Human / chemistry*
  • Parvovirus B19, Human / genetics
  • Predictive Value of Tests
  • Pruritus / virology
  • Purpura / virology

Substances

  • Capsid Proteins
  • DNA, Viral
  • capsid protein VP2, parvovirus B19