Microbiological stability of solutions containing local anesthetics and opioids in closed infusion systems used for epidural analgesia

Pharmazie. 2011 Oct;66(10):810.

Abstract

Nine solutions containing opiod analgesics and local anesthetics as typically use in epidural catheters were tested for antimicrobial stability. Administration via a pefusor syringe requires several refill processes. It was shown that repetitive refilling of the syringes did not result in any microbiological contamination.

MeSH terms

  • Amides / analysis
  • Analgesics, Opioid / analysis*
  • Anesthesia, Epidural*
  • Anesthetics, Local / analysis*
  • Drug Compounding
  • Drug Contamination*
  • Fentanyl / analysis
  • Infusion Pumps
  • Infusions, Intravenous
  • Pain Clinics
  • Ropivacaine
  • Solutions
  • Staphylococcus epidermidis
  • Syringes

Substances

  • Amides
  • Analgesics, Opioid
  • Anesthetics, Local
  • Solutions
  • Ropivacaine
  • Fentanyl