Abstract
A 36-year-old man with a prior diagnosis of primary cutaneous marginal-zone B cell lymphoma presented with newly-developed, small, erythematous papules and nodules on his upper left arm and pink-to-skin-colored, clustered papules on his left forearm. A biopsy specimen and immunohistochemical analysis of the left arm lesions showed a lymphocytic infiltrate which stained positively for CD20 and Bcl-2 and negatively for CD10. A PET-CT scan was negative for any extra-cutaneous manifestations of disease. These clinicopathologic findings are indicative of recurrent localized primary cutaneous marginal-zone B cell lymphoma.
MeSH terms
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Adult
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Antigens, CD20 / analysis
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Arm
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Bexarotene
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Biomarkers, Tumor / analysis
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Biopsy
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Combined Modality Therapy
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Humans
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Ki-67 Antigen / analysis
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Lymphoma, B-Cell, Marginal Zone / chemistry
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Lymphoma, B-Cell, Marginal Zone / diagnosis*
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Lymphoma, B-Cell, Marginal Zone / drug therapy
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Lymphoma, B-Cell, Marginal Zone / pathology
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Lymphoma, B-Cell, Marginal Zone / radiotherapy
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Male
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Neoplasm Recurrence, Local / chemistry
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Neoplasm Recurrence, Local / diagnosis*
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Neoplasm Recurrence, Local / drug therapy
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Neoplasm Recurrence, Local / pathology
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Neoplasm Recurrence, Local / radiotherapy
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Proto-Oncogene Proteins c-bcl-2 / analysis
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Skin Neoplasms / chemistry
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Skin Neoplasms / diagnosis*
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Skin Neoplasms / drug therapy
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Skin Neoplasms / pathology
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Skin Neoplasms / radiotherapy
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Tetrahydronaphthalenes / therapeutic use
Substances
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Antigens, CD20
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Biomarkers, Tumor
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Ki-67 Antigen
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Proto-Oncogene Proteins c-bcl-2
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Tetrahydronaphthalenes
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Bexarotene