Contraceptive failure of etonogestrel implant in patients treated with antiretrovirals including efavirenz

Contraception. 2012 Apr;85(4):425-7. doi: 10.1016/j.contraception.2011.09.005. Epub 2011 Oct 27.

Abstract

Contraception for HIV-positive women is a complex issue. Although the use of condoms is recommended, complementary methods of contraception are often prescribed. Antiretroviral therapy can lead to drug interactions and modify the efficacy of hormonal contraception. Two unintended pregnancies suggest that etonogestrel implants should be used with caution in patients on efavirenz.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alkynes
  • Anti-Retroviral Agents / adverse effects*
  • Anti-Retroviral Agents / therapeutic use
  • Benzoxazines / adverse effects*
  • Benzoxazines / therapeutic use
  • Condoms
  • Contraceptive Agents, Female / administration & dosage*
  • Cyclopropanes
  • Desogestrel / administration & dosage*
  • Drug Interactions
  • Female
  • HIV Infections / drug therapy*
  • Humans
  • Pregnancy
  • Pregnancy, Unplanned*

Substances

  • Alkynes
  • Anti-Retroviral Agents
  • Benzoxazines
  • Contraceptive Agents, Female
  • Cyclopropanes
  • etonogestrel
  • Desogestrel
  • efavirenz