No seasonal variation in human midbrain serotonin transporter availability in Taiwan

Yu Shian Cheng; Kao Chin Chen; Yen Kuang Yang; Po See Chen; Tzung Lieh Yeh; I Hui Lee; Yun-Hsuan Chang; Mei-Hsiu Liao

doi:10.1016/j.pscychresns.2011.04.005

No seasonal variation in human midbrain serotonin transporter availability in Taiwan

Psychiatry Res. 2011 Dec 30;194(3):396-399. doi: 10.1016/j.pscychresns.2011.04.005. Epub 2011 Oct 30.

Authors

Yu Shian Cheng¹, Kao Chin Chen², Yen Kuang Yang², Po See Chen³, Tzung Lieh Yeh², I Hui Lee⁴, Yun-Hsuan Chang⁵, Mei-Hsiu Liao⁶

Affiliations

¹ Department of Psychiatry, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
² Department of Psychiatry, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
³ Department of Psychiatry, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry, College of Medicine, National Cheng Kung University Hospital, Douliou Branch, Yunlin, Taiwan.
⁴ Department of Psychiatry, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: [email protected].
⁵ Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Division of Clinical Psychology, Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁶ Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, Taoyun, Taiwan.

PMID: 22041533
DOI: 10.1016/j.pscychresns.2011.04.005

Abstract

Sunlight exposure is considered responsible for seasonal serotonin changes. Sixty-six healthy participants were recruited, and single photon emission computed tomography ([¹²³I]-ADAM SPECT) was used to investigate the association between serotonin transporter (SERT) availability and duration of sunlight exposure in Taiwan, a subtropical country. No significant correlation between SERT availability and the duration of sunlight exposure was found.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cinanserin / analogs & derivatives
Cinanserin / pharmacokinetics
Female
Humans
Iodine Radioisotopes / pharmacokinetics
Male
Mesencephalon / diagnostic imaging*
Seasons*
Serotonin Plasma Membrane Transport Proteins / metabolism*
Taiwan
Tomography, Emission-Computed, Single-Photon
Young Adult

Substances

2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine
Iodine Radioisotopes
Serotonin Plasma Membrane Transport Proteins
Cinanserin